Season 6: Inspired by actual cases and experiences, Numb3rs depicts the confluence of police work and mathematics in solving crime. An FBI agent recruits his mathematical genius brother to help solve a wide range of challenging crimes in Los Angeles from a very different perspective.

Cast: Judd Hirsch, Rob Morrow and David Krumholtz.

A dedicated FBI agent, Don Eppes, couldn't be more different from his younger brother, Charlie Eppes, a brilliant mathematician who, since he was little, yearned to impress his big brother. Don is joined on his team by fellow agents David Sinclair, who utilizes his incredible perspective and the survival skills he learned growing up in the Bronx; Colby Granger, an Army veteran once stationed in the Middle East, who brings with him innovative methods to crime-solving; Liz Warner, a special agent who is also a former romantic interest of Don's; and newest agent Nikki Betancourt, a tough, street-smart ex-LAPD officer whose way of handling cases won't exactly mesh with how Don runs his team.

Don and Charlie's father, Alan, is happy to see his sons working together even though he doesn't understand the intricacies of what Charlie does for a living. It is his co-workers at CalSci who further refine Charlie's approach and help him stay focused. Physicist friend Dr. Larry Fleinhardt constantly challenges Charlie to employ a broader point of view to his work with the FBI, and Amita Ramanjuan, Charlie's girlfriend and former grad student, frequently helps him see cases in a new light Despite their disparate approaches to life, Don and Charlie are able to combine their areas of expertise and solve some killer cases.